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Test-NO8.Rmd

Report NO8

Table of Contents

1 PK parameters

1.1 PK Parameters of C1 plasma

1.1.1 AUC_tEnd

Figure 1-1: AUC_tEnd of C1 plasma for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.



Figure 1-2: AUC_tEnd of C1 plasma for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.



Table 1-1: Population statistics summarizing AUC_tEnd of C1 plasma for single IV application reported in [µg*h/l]

Population N 5th pctl 25th pctl 50th pctl 75th pctl 95th pctl Mean SD Geo Mean Geo SD
single IV application 10 4075.97 5514.62 6570.16 9155.63 14441.17 7871.54 3884.11 7138.17 1.58



1.1.2 C_max

Figure 1-3: C_max of C1 plasma for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.



Figure 1-4: C_max of C1 plasma for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.



Table 1-2: Population statistics summarizing C_max of C1 plasma for single IV application reported in [mg/l]

Population N 5th pctl 25th pctl 50th pctl 75th pctl 95th pctl Mean SD Geo Mean Geo SD
single IV application 10 3.48 3.67 4.14 4.37 5.04 4.15 0.57 4.11 1.15



1.1.3 C_tEnd

Figure 1-5: C_tEnd of C1 plasma for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.



Figure 1-6: C_tEnd of C1 plasma for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.



Table 1-3: Population statistics summarizing C_tEnd of C1 plasma for single IV application reported in [µg/l]

Population N 5th pctl 25th pctl 50th pctl 75th pctl 95th pctl Mean SD Geo Mean Geo SD
single IV application 10 2.02 7.34 15.17 49.28 209.28 54.66 85.33 17.95 5.24



1.1.4 t_max

Figure 1-7: t_max of C1 plasma for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.



Figure 1-8: t_max of C1 plasma for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.



Table 1-4: Population statistics summarizing t_max of C1 plasma for single IV application reported in [h]

Population N 5th pctl 25th pctl 50th pctl 75th pctl 95th pctl Mean SD Geo Mean Geo SD
single IV application 10 0.05 0.05 0.05 0.05 0.05 0.05 0 0.05 1



1.1.5 Total body clearance/F

Figure 1-9: Total body clearance/F of C1 plasma for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.



Figure 1-10: Total body clearance/F of C1 plasma for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.



Table 1-5: Population statistics summarizing Total body clearance/F of C1 plasma for single IV application reported in [ml/min/kg]

Population N 5th pctl 25th pctl 50th pctl 75th pctl 95th pctl Mean SD Geo Mean Geo SD
single IV application 10 0.99 1.75 2.54 3.00 4.08 2.48 1.11 2.23 1.68



1.1.6 Vss (plasma)/F

Figure 1-11: Vss (plasma)/F of C1 plasma for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.



Figure 1-12: Vss (plasma)/F of C1 plasma for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.



Table 1-6: Population statistics summarizing Vss (plasma)/F of C1 plasma for single IV application reported in [ml/kg]

Population N 5th pctl 25th pctl 50th pctl 75th pctl 95th pctl Mean SD Geo Mean Geo SD
single IV application 10 734.12 745.67 768.91 796.82 806.49 769.28 28.85 768.80 1.04



1.2 PK Parameters of C1 Bone

1.2.1 AUC_tEnd

Figure 1-13: AUC_tEnd of C1 Bone for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.



Figure 1-14: AUC_tEnd of C1 Bone for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.



Table 1-7: Population statistics summarizing AUC_tEnd of C1 Bone for single IV application reported in [µg*h/l]

Population N 5th pctl 25th pctl 50th pctl 75th pctl 95th pctl Mean SD Geo Mean Geo SD
single IV application 10 2570.57 3501.21 4022.85 5630.44 9128.23 4935.11 2438.81 4476.05 1.58



1.2.2 C_max

Figure 1-15: C_max of C1 Bone for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.



Figure 1-16: C_max of C1 Bone for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.



Table 1-8: Population statistics summarizing C_max of C1 Bone for single IV application reported in [mg/l]

Population N 5th pctl 25th pctl 50th pctl 75th pctl 95th pctl Mean SD Geo Mean Geo SD
single IV application 10 0.79 0.83 0.87 0.91 1.00 0.88 0.08 0.88 1.09



1.2.3 C_tEnd

Figure 1-17: C_tEnd of C1 Bone for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.



Figure 1-18: C_tEnd of C1 Bone for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.



Table 1-9: Population statistics summarizing C_tEnd of C1 Bone for single IV application reported in [µg/l]

Population N 5th pctl 25th pctl 50th pctl 75th pctl 95th pctl Mean SD Geo Mean Geo SD
single IV application 10 1.20 4.62 9.44 31.14 133.83 34.88 54.24 11.23 5.37



1.2.4 t_max

Figure 1-19: t_max of C1 Bone for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.



Figure 1-20: t_max of C1 Bone for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.



Table 1-10: Population statistics summarizing t_max of C1 Bone for single IV application reported in [h]

Population N 5th pctl 25th pctl 50th pctl 75th pctl 95th pctl Mean SD Geo Mean Geo SD
single IV application 10 0.27 0.30 0.32 0.35 0.40 0.33 0.05 0.33 1.16



1.2.5 Total body clearance/F

Figure 1-21: Total body clearance/F of C1 Bone for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.



Figure 1-22: Total body clearance/F of C1 Bone for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.



Table 1-11: Population statistics summarizing Total body clearance/F of C1 Bone for single IV application reported in [ml/min/kg]

Population N 5th pctl 25th pctl 50th pctl 75th pctl 95th pctl Mean SD Geo Mean Geo SD
single IV application 10 1.56 2.84 4.14 4.73 6.47 3.96 1.76 3.55 1.68



1.2.6 Vss (plasma)/F

Figure 1-23: Vss (plasma)/F of C1 Bone for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.



Figure 1-24: Vss (plasma)/F of C1 Bone for single IV application shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.



Table 1-12: Population statistics summarizing Vss (plasma)/F of C1 Bone for single IV application reported in [ml/kg]

Population N 5th pctl 25th pctl 50th pctl 75th pctl 95th pctl Mean SD Geo Mean Geo SD
single IV application 10 1199.38 1241.55 1278.98 1311.51 1372.41 1279.85 62.10 1278.50 1.05



2 Time profiles and residual plots

2.1 Time profiles and residual plots for single IV application

Figure 2-1: Time profiles for single IV application. Time profiles are plotted in a linear scale.



Figure 2-2: Time profiles for single IV application. Time profiles are plotted in a logarithmic scale.



Figure 2-3: Time profiles for single IV application. Time profiles are plotted in a linear scale.



Figure 2-4: Time profiles for single IV application. Time profiles are plotted in a logarithmic scale.



3 Demography

3.1 Age distributions

3.1.1 For single IV application

Figure 3-1: Distribution of Age for single IV application.



3.2 Height distributions

3.2.1 For single IV application

Figure 3-2: Distribution of Height for single IV application.



3.3 Weight distributions

3.3.1 For single IV application

Figure 3-3: Distribution of Weight for single IV application.



3.4 BMI distributions

3.4.1 For single IV application

Figure 3-4: Distribution of BMI for single IV application.



3.5 Gender distributions

3.5.1 For single IV application

Figure 3-5: Distribution of Gender for single IV application.