Test-NO10.RmdTable of Contents
1 PK parameters
1.1 PK Parameters of C1 plasma
1.1.1 AUC_tEnd
Figure 1-1: AUC_tEnd of C1 plasma for single IV administration, children_0_3y, children_3_6y, children_6_9y shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.
Figure 1-2: AUC_tEnd of C1 plasma for single IV administration, children_0_3y, children_3_6y, children_6_9y shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.
Table 1-1: Population statistics summarizing AUC_tEnd of C1 plasma for single IV administration, children_0_3y, children_3_6y, children_6_9y reported in [µg*h/l]
| Population | N | 5th pctl | 25th pctl | 50th pctl | 75th pctl | 95th pctl | Mean | SD | Geo Mean | Geo SD |
|---|---|---|---|---|---|---|---|---|---|---|
| single IV administration | 10 | 8843.16 | 9408.69 | 11804.59 | 13514.22 | 16208.15 | 11945.12 | 2899.61 | 11645.31 | 1.27 |
| children_0_3y | 5 | 10180.61 | 11060.57 | 12511.74 | 16127.16 | 16812.38 | 13328.76 | 3096.21 | 13043.50 | 1.26 |
| children_3_6y | 5 | 12619.16 | 12676.50 | 12862.73 | 16120.44 | 17498.06 | 14421.39 | 2416.84 | 14267.25 | 1.18 |
| children_6_9y | 5 | 11633.07 | 13294.59 | 16361.30 | 16819.53 | 17066.94 | 14964.38 | 2593.43 | 14770.23 | 1.20 |
Figure 1-3: Age-dependence of AUC_tEnd for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-4: Age-dependence of AUC_tEnd for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-5: Age-dependence of AUC_tEnd for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-6: Age-dependence of AUC_tEnd for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-7: Age-dependence of AUC_tEnd for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-8: Age-dependence of AUC_tEnd for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-9: Age-dependence of AUC_tEnd for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-10: Age-dependence of AUC_tEnd for single IV administration. Profiles are plotted in a linear scale.
Figure 1-11: Age-dependence of AUC_tEnd for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-12: Age-dependence of AUC_tEnd for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-13: Age-dependence of AUC_tEnd for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-14: Age-dependence of AUC_tEnd for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-15: Age-dependence of AUC_tEnd for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-16: Age-dependence of AUC_tEnd for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-17: Height-dependence of AUC_tEnd for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-18: Height-dependence of AUC_tEnd for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-19: Height-dependence of AUC_tEnd for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-20: Height-dependence of AUC_tEnd for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-21: Height-dependence of AUC_tEnd for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-22: Height-dependence of AUC_tEnd for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-23: Height-dependence of AUC_tEnd for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-24: Height-dependence of AUC_tEnd for single IV administration. Profiles are plotted in a linear scale.
Figure 1-25: Height-dependence of AUC_tEnd for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-26: Height-dependence of AUC_tEnd for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-27: Height-dependence of AUC_tEnd for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-28: Height-dependence of AUC_tEnd for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-29: Height-dependence of AUC_tEnd for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-30: Height-dependence of AUC_tEnd for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-31: Weight-dependence of AUC_tEnd for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-32: Weight-dependence of AUC_tEnd for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-33: Weight-dependence of AUC_tEnd for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-34: Weight-dependence of AUC_tEnd for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-35: Weight-dependence of AUC_tEnd for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-36: Weight-dependence of AUC_tEnd for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-37: Weight-dependence of AUC_tEnd for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-38: Weight-dependence of AUC_tEnd for single IV administration. Profiles are plotted in a linear scale.
Figure 1-39: Weight-dependence of AUC_tEnd for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-40: Weight-dependence of AUC_tEnd for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-41: Weight-dependence of AUC_tEnd for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-42: Weight-dependence of AUC_tEnd for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-43: Weight-dependence of AUC_tEnd for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-44: Weight-dependence of AUC_tEnd for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-45: BMI-dependence of AUC_tEnd for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-46: BMI-dependence of AUC_tEnd for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-47: BMI-dependence of AUC_tEnd for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-48: BMI-dependence of AUC_tEnd for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-49: BMI-dependence of AUC_tEnd for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-50: BMI-dependence of AUC_tEnd for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-51: BMI-dependence of AUC_tEnd for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-52: BMI-dependence of AUC_tEnd for single IV administration. Profiles are plotted in a linear scale.
Figure 1-53: BMI-dependence of AUC_tEnd for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-54: BMI-dependence of AUC_tEnd for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-55: BMI-dependence of AUC_tEnd for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-56: BMI-dependence of AUC_tEnd for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-57: BMI-dependence of AUC_tEnd for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-58: BMI-dependence of AUC_tEnd for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-59: Ratio of population summary statistics of AUC_tEnd of C1 plasma for children_0_3y, children_3_6y, children_6_9y in comparison to single IV administration shown as box-whisker plot, which indicates ratios of the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.
Figure 1-60: Ratio of population summary statistics of AUC_tEnd of C1 plasma for children_0_3y, children_3_6y, children_6_9y in comparison to single IV administration shown as box-whisker plot, which indicates ratios of the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.
Table 1-2: Ratio of population summary statistics of AUC_tEnd of C1 plasma for children_0_3y, children_3_6y, children_6_9y in comparison to single IV administration
| Population | N | 5th pctl | 25th pctl | 50th pctl | 75th pctl | 95th pctl | Mean | SD | Geo Mean | Geo SD |
|---|---|---|---|---|---|---|---|---|---|---|
| children_0_3y | 5 | 1.15 | 1.18 | 1.06 | 1.19 | 1.04 | 1.12 | 1.07 | 1.12 | 1.00 |
| children_3_6y | 5 | 1.43 | 1.35 | 1.09 | 1.19 | 1.08 | 1.21 | 0.83 | 1.23 | 0.93 |
| children_6_9y | 5 | 1.32 | 1.41 | 1.39 | 1.24 | 1.05 | 1.25 | 0.89 | 1.27 | 0.95 |
1.1.2 C_max
Figure 1-61: C_max of C1 plasma for single IV administration, children_0_3y, children_3_6y, children_6_9y shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.
Figure 1-62: C_max of C1 plasma for single IV administration, children_0_3y, children_3_6y, children_6_9y shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.
Table 1-3: Population statistics summarizing C_max of C1 plasma for single IV administration, children_0_3y, children_3_6y, children_6_9y reported in [µg/l]
| Population | N | 5th pctl | 25th pctl | 50th pctl | 75th pctl | 95th pctl | Mean | SD | Geo Mean | Geo SD |
|---|---|---|---|---|---|---|---|---|---|---|
| single IV administration | 10 | 3302.16 | 3405.09 | 3757.09 | 4221.53 | 4473.51 | 3821.55 | 470.40 | 3795.86 | 1.13 |
| children_0_3y | 5 | 3106.38 | 3303.05 | 3395.22 | 3855.09 | 3948.88 | 3516.58 | 385.24 | 3499.75 | 1.12 |
| children_3_6y | 5 | 2812.86 | 2932.02 | 3303.99 | 3382.07 | 3415.62 | 3165.03 | 288.82 | 3154.20 | 1.10 |
| children_6_9y | 5 | 3124.12 | 3304.15 | 3562.26 | 3768.33 | 3921.70 | 3534.78 | 352.48 | 3520.56 | 1.11 |
Figure 1-63: Age-dependence of C_max for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-64: Age-dependence of C_max for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-65: Age-dependence of C_max for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-66: Age-dependence of C_max for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-67: Age-dependence of C_max for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-68: Age-dependence of C_max for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-69: Age-dependence of C_max for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-70: Age-dependence of C_max for single IV administration. Profiles are plotted in a linear scale.
Figure 1-71: Age-dependence of C_max for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-72: Age-dependence of C_max for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-73: Age-dependence of C_max for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-74: Age-dependence of C_max for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-75: Age-dependence of C_max for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-76: Age-dependence of C_max for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-77: Height-dependence of C_max for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-78: Height-dependence of C_max for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-79: Height-dependence of C_max for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-80: Height-dependence of C_max for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-81: Height-dependence of C_max for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-82: Height-dependence of C_max for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-83: Height-dependence of C_max for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-84: Height-dependence of C_max for single IV administration. Profiles are plotted in a linear scale.
Figure 1-85: Height-dependence of C_max for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-86: Height-dependence of C_max for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-87: Height-dependence of C_max for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-88: Height-dependence of C_max for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-89: Height-dependence of C_max for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-90: Height-dependence of C_max for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-91: Weight-dependence of C_max for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-92: Weight-dependence of C_max for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-93: Weight-dependence of C_max for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-94: Weight-dependence of C_max for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-95: Weight-dependence of C_max for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-96: Weight-dependence of C_max for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-97: Weight-dependence of C_max for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-98: Weight-dependence of C_max for single IV administration. Profiles are plotted in a linear scale.
Figure 1-99: Weight-dependence of C_max for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-100: Weight-dependence of C_max for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-101: Weight-dependence of C_max for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-102: Weight-dependence of C_max for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-103: Weight-dependence of C_max for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-104: Weight-dependence of C_max for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-105: BMI-dependence of C_max for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-106: BMI-dependence of C_max for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-107: BMI-dependence of C_max for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-108: BMI-dependence of C_max for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-109: BMI-dependence of C_max for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-110: BMI-dependence of C_max for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-111: BMI-dependence of C_max for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-112: BMI-dependence of C_max for single IV administration. Profiles are plotted in a linear scale.
Figure 1-113: BMI-dependence of C_max for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-114: BMI-dependence of C_max for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-115: BMI-dependence of C_max for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-116: BMI-dependence of C_max for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-117: BMI-dependence of C_max for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-118: BMI-dependence of C_max for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-119: Ratio of population summary statistics of C_max of C1 plasma for children_0_3y, children_3_6y, children_6_9y in comparison to single IV administration shown as box-whisker plot, which indicates ratios of the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.
Figure 1-120: Ratio of population summary statistics of C_max of C1 plasma for children_0_3y, children_3_6y, children_6_9y in comparison to single IV administration shown as box-whisker plot, which indicates ratios of the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.
Table 1-4: Ratio of population summary statistics of C_max of C1 plasma for children_0_3y, children_3_6y, children_6_9y in comparison to single IV administration
| Population | N | 5th pctl | 25th pctl | 50th pctl | 75th pctl | 95th pctl | Mean | SD | Geo Mean | Geo SD |
|---|---|---|---|---|---|---|---|---|---|---|
| children_0_3y | 5 | 0.94 | 0.97 | 0.90 | 0.91 | 0.88 | 0.92 | 0.82 | 0.92 | 0.99 |
| children_3_6y | 5 | 0.85 | 0.86 | 0.88 | 0.80 | 0.76 | 0.83 | 0.61 | 0.83 | 0.97 |
| children_6_9y | 5 | 0.95 | 0.97 | 0.95 | 0.89 | 0.88 | 0.92 | 0.75 | 0.93 | 0.98 |
1.1.3 C_tEnd
Figure 1-121: C_tEnd of C1 plasma for single IV administration, children_0_3y, children_3_6y, children_6_9y shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.
Figure 1-122: C_tEnd of C1 plasma for single IV administration, children_0_3y, children_3_6y, children_6_9y shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.
Table 1-5: Population statistics summarizing C_tEnd of C1 plasma for single IV administration, children_0_3y, children_3_6y, children_6_9y reported in [µg/l]
| Population | N | 5th pctl | 25th pctl | 50th pctl | 75th pctl | 95th pctl | Mean | SD | Geo Mean | Geo SD |
|---|---|---|---|---|---|---|---|---|---|---|
| single IV administration | 10 | 293.81 | 311.03 | 406.87 | 459.20 | 552.40 | 404.54 | 102.70 | 393.41 | 1.28 |
| children_0_3y | 5 | 363.81 | 404.48 | 462.65 | 591.82 | 624.99 | 489.18 | 119.95 | 477.42 | 1.28 |
| children_3_6y | 5 | 479.32 | 481.84 | 482.89 | 617.71 | 664.82 | 547.54 | 93.29 | 541.48 | 1.18 |
| children_6_9y | 5 | 432.81 | 497.25 | 625.43 | 651.28 | 656.48 | 569.69 | 107.44 | 560.90 | 1.22 |
Figure 1-123: Age-dependence of C_tEnd for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-124: Age-dependence of C_tEnd for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-125: Age-dependence of C_tEnd for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-126: Age-dependence of C_tEnd for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-127: Age-dependence of C_tEnd for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-128: Age-dependence of C_tEnd for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-129: Age-dependence of C_tEnd for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-130: Age-dependence of C_tEnd for single IV administration. Profiles are plotted in a linear scale.
Figure 1-131: Age-dependence of C_tEnd for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-132: Age-dependence of C_tEnd for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-133: Age-dependence of C_tEnd for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-134: Age-dependence of C_tEnd for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-135: Age-dependence of C_tEnd for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-136: Age-dependence of C_tEnd for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-137: Height-dependence of C_tEnd for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-138: Height-dependence of C_tEnd for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-139: Height-dependence of C_tEnd for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-140: Height-dependence of C_tEnd for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-141: Height-dependence of C_tEnd for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-142: Height-dependence of C_tEnd for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-143: Height-dependence of C_tEnd for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-144: Height-dependence of C_tEnd for single IV administration. Profiles are plotted in a linear scale.
Figure 1-145: Height-dependence of C_tEnd for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-146: Height-dependence of C_tEnd for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-147: Height-dependence of C_tEnd for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-148: Height-dependence of C_tEnd for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-149: Height-dependence of C_tEnd for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-150: Height-dependence of C_tEnd for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-151: Weight-dependence of C_tEnd for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-152: Weight-dependence of C_tEnd for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-153: Weight-dependence of C_tEnd for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-154: Weight-dependence of C_tEnd for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-155: Weight-dependence of C_tEnd for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-156: Weight-dependence of C_tEnd for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-157: Weight-dependence of C_tEnd for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-158: Weight-dependence of C_tEnd for single IV administration. Profiles are plotted in a linear scale.
Figure 1-159: Weight-dependence of C_tEnd for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-160: Weight-dependence of C_tEnd for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-161: Weight-dependence of C_tEnd for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-162: Weight-dependence of C_tEnd for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-163: Weight-dependence of C_tEnd for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-164: Weight-dependence of C_tEnd for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-165: BMI-dependence of C_tEnd for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-166: BMI-dependence of C_tEnd for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-167: BMI-dependence of C_tEnd for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-168: BMI-dependence of C_tEnd for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-169: BMI-dependence of C_tEnd for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-170: BMI-dependence of C_tEnd for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-171: BMI-dependence of C_tEnd for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-172: BMI-dependence of C_tEnd for single IV administration. Profiles are plotted in a linear scale.
Figure 1-173: BMI-dependence of C_tEnd for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-174: BMI-dependence of C_tEnd for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-175: BMI-dependence of C_tEnd for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-176: BMI-dependence of C_tEnd for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-177: BMI-dependence of C_tEnd for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-178: BMI-dependence of C_tEnd for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-179: Ratio of population summary statistics of C_tEnd of C1 plasma for children_0_3y, children_3_6y, children_6_9y in comparison to single IV administration shown as box-whisker plot, which indicates ratios of the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.
Figure 1-180: Ratio of population summary statistics of C_tEnd of C1 plasma for children_0_3y, children_3_6y, children_6_9y in comparison to single IV administration shown as box-whisker plot, which indicates ratios of the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.
Table 1-6: Ratio of population summary statistics of C_tEnd of C1 plasma for children_0_3y, children_3_6y, children_6_9y in comparison to single IV administration
| Population | N | 5th pctl | 25th pctl | 50th pctl | 75th pctl | 95th pctl | Mean | SD | Geo Mean | Geo SD |
|---|---|---|---|---|---|---|---|---|---|---|
| children_0_3y | 5 | 1.24 | 1.30 | 1.14 | 1.29 | 1.13 | 1.21 | 1.17 | 1.21 | 1.00 |
| children_3_6y | 5 | 1.63 | 1.55 | 1.19 | 1.35 | 1.20 | 1.35 | 0.91 | 1.38 | 0.92 |
| children_6_9y | 5 | 1.47 | 1.60 | 1.54 | 1.42 | 1.19 | 1.41 | 1.05 | 1.43 | 0.96 |
1.1.4 t_max
Figure 1-181: t_max of C1 plasma for single IV administration, children_0_3y, children_3_6y, children_6_9y shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.
Figure 1-182: t_max of C1 plasma for single IV administration, children_0_3y, children_3_6y, children_6_9y shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.
Table 1-7: Population statistics summarizing t_max of C1 plasma for single IV administration, children_0_3y, children_3_6y, children_6_9y reported in [h]
| Population | N | 5th pctl | 25th pctl | 50th pctl | 75th pctl | 95th pctl | Mean | SD | Geo Mean | Geo SD |
|---|---|---|---|---|---|---|---|---|---|---|
| single IV administration | 10 | 0.05 | 0.05 | 0.05 | 0.05 | 0.05 | 0.05 | 0 | 0.05 | 1 |
| children_0_3y | 5 | 0.05 | 0.05 | 0.05 | 0.05 | 0.05 | 0.05 | 0 | 0.05 | 1 |
| children_3_6y | 5 | 0.05 | 0.05 | 0.05 | 0.05 | 0.05 | 0.05 | 0 | 0.05 | 1 |
| children_6_9y | 5 | 0.05 | 0.05 | 0.05 | 0.05 | 0.05 | 0.05 | 0 | 0.05 | 1 |
Figure 1-183: Age-dependence of t_max for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-184: Age-dependence of t_max for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-185: Age-dependence of t_max for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-186: Age-dependence of t_max for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-187: Age-dependence of t_max for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-188: Age-dependence of t_max for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-189: Age-dependence of t_max for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-190: Age-dependence of t_max for single IV administration. Profiles are plotted in a linear scale.
Figure 1-191: Age-dependence of t_max for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-192: Age-dependence of t_max for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-193: Age-dependence of t_max for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-194: Age-dependence of t_max for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-195: Age-dependence of t_max for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-196: Age-dependence of t_max for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-197: Height-dependence of t_max for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-198: Height-dependence of t_max for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-199: Height-dependence of t_max for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-200: Height-dependence of t_max for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-201: Height-dependence of t_max for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-202: Height-dependence of t_max for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-203: Height-dependence of t_max for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-204: Height-dependence of t_max for single IV administration. Profiles are plotted in a linear scale.
Figure 1-205: Height-dependence of t_max for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-206: Height-dependence of t_max for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-207: Height-dependence of t_max for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-208: Height-dependence of t_max for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-209: Height-dependence of t_max for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-210: Height-dependence of t_max for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-211: Weight-dependence of t_max for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-212: Weight-dependence of t_max for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-213: Weight-dependence of t_max for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-214: Weight-dependence of t_max for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-215: Weight-dependence of t_max for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-216: Weight-dependence of t_max for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-217: Weight-dependence of t_max for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-218: Weight-dependence of t_max for single IV administration. Profiles are plotted in a linear scale.
Figure 1-219: Weight-dependence of t_max for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-220: Weight-dependence of t_max for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-221: Weight-dependence of t_max for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-222: Weight-dependence of t_max for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-223: Weight-dependence of t_max for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-224: Weight-dependence of t_max for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-225: BMI-dependence of t_max for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-226: BMI-dependence of t_max for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-227: BMI-dependence of t_max for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-228: BMI-dependence of t_max for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-229: BMI-dependence of t_max for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-230: BMI-dependence of t_max for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-231: BMI-dependence of t_max for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-232: BMI-dependence of t_max for single IV administration. Profiles are plotted in a linear scale.
Figure 1-233: BMI-dependence of t_max for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-234: BMI-dependence of t_max for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-235: BMI-dependence of t_max for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-236: BMI-dependence of t_max for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-237: BMI-dependence of t_max for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-238: BMI-dependence of t_max for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-239: Ratio of population summary statistics of t_max of C1 plasma for children_0_3y, children_3_6y, children_6_9y in comparison to single IV administration shown as box-whisker plot, which indicates ratios of the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.
Figure 1-240: Ratio of population summary statistics of t_max of C1 plasma for children_0_3y, children_3_6y, children_6_9y in comparison to single IV administration shown as box-whisker plot, which indicates ratios of the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.
Table 1-8: Ratio of population summary statistics of t_max of C1 plasma for children_0_3y, children_3_6y, children_6_9y in comparison to single IV administration
| Population | N | 5th pctl | 25th pctl | 50th pctl | 75th pctl | 95th pctl | Mean | SD | Geo Mean | Geo SD |
|---|---|---|---|---|---|---|---|---|---|---|
| children_0_3y | 5 | 1 | 1 | 1 | 1 | 1 | 1 | - | 1 | 1 |
| children_3_6y | 5 | 1 | 1 | 1 | 1 | 1 | 1 | - | 1 | 1 |
| children_6_9y | 5 | 1 | 1 | 1 | 1 | 1 | 1 | - | 1 | 1 |
1.1.5 Total body clearance/F
Figure 1-241: Total body clearance/F of C1 plasma for single IV administration, children_0_3y, children_3_6y, children_6_9y shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.
Figure 1-242: Total body clearance/F of C1 plasma for single IV administration, children_0_3y, children_3_6y, children_6_9y shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.
Table 1-9: Population statistics summarizing Total body clearance/F of C1 plasma for single IV administration, children_0_3y, children_3_6y, children_6_9y reported in [ml/min/kg]
| Population | N | 5th pctl | 25th pctl | 50th pctl | 75th pctl | 95th pctl | Mean | SD | Geo Mean | Geo SD |
|---|---|---|---|---|---|---|---|---|---|---|
| single IV administration | 10 | 0.00 | 0.00 | 0.01 | 0.01 | 0.01 | 0.01 | 0.00 | 0.01 | 1.87 |
| children_0_3y | 5 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.45 |
| children_3_6y | 5 | 0.00 | 0.00 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 1.18 |
| children_6_9y | 5 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 1.20 |
Figure 1-243: Age-dependence of Total body clearance/F for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-244: Age-dependence of Total body clearance/F for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-245: Age-dependence of Total body clearance/F for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-246: Age-dependence of Total body clearance/F for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-247: Age-dependence of Total body clearance/F for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-248: Age-dependence of Total body clearance/F for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-249: Age-dependence of Total body clearance/F for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-250: Age-dependence of Total body clearance/F for single IV administration. Profiles are plotted in a linear scale.
Figure 1-251: Age-dependence of Total body clearance/F for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-252: Age-dependence of Total body clearance/F for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-253: Age-dependence of Total body clearance/F for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-254: Age-dependence of Total body clearance/F for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-255: Age-dependence of Total body clearance/F for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-256: Age-dependence of Total body clearance/F for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-257: Height-dependence of Total body clearance/F for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-258: Height-dependence of Total body clearance/F for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-259: Height-dependence of Total body clearance/F for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-260: Height-dependence of Total body clearance/F for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-261: Height-dependence of Total body clearance/F for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-262: Height-dependence of Total body clearance/F for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-263: Height-dependence of Total body clearance/F for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-264: Height-dependence of Total body clearance/F for single IV administration. Profiles are plotted in a linear scale.
Figure 1-265: Height-dependence of Total body clearance/F for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-266: Height-dependence of Total body clearance/F for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-267: Height-dependence of Total body clearance/F for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-268: Height-dependence of Total body clearance/F for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-269: Height-dependence of Total body clearance/F for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-270: Height-dependence of Total body clearance/F for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-271: Weight-dependence of Total body clearance/F for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-272: Weight-dependence of Total body clearance/F for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-273: Weight-dependence of Total body clearance/F for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-274: Weight-dependence of Total body clearance/F for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-275: Weight-dependence of Total body clearance/F for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-276: Weight-dependence of Total body clearance/F for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-277: Weight-dependence of Total body clearance/F for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-278: Weight-dependence of Total body clearance/F for single IV administration. Profiles are plotted in a linear scale.
Figure 1-279: Weight-dependence of Total body clearance/F for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-280: Weight-dependence of Total body clearance/F for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-281: Weight-dependence of Total body clearance/F for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-282: Weight-dependence of Total body clearance/F for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-283: Weight-dependence of Total body clearance/F for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-284: Weight-dependence of Total body clearance/F for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-285: BMI-dependence of Total body clearance/F for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-286: BMI-dependence of Total body clearance/F for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-287: BMI-dependence of Total body clearance/F for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-288: BMI-dependence of Total body clearance/F for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-289: BMI-dependence of Total body clearance/F for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-290: BMI-dependence of Total body clearance/F for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-291: BMI-dependence of Total body clearance/F for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-292: BMI-dependence of Total body clearance/F for single IV administration. Profiles are plotted in a linear scale.
Figure 1-293: BMI-dependence of Total body clearance/F for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-294: BMI-dependence of Total body clearance/F for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-295: BMI-dependence of Total body clearance/F for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-296: BMI-dependence of Total body clearance/F for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-297: BMI-dependence of Total body clearance/F for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-298: BMI-dependence of Total body clearance/F for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-299: Ratio of population summary statistics of Total body clearance/F of C1 plasma for children_0_3y, children_3_6y, children_6_9y in comparison to single IV administration shown as box-whisker plot, which indicates ratios of the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.
Figure 1-300: Ratio of population summary statistics of Total body clearance/F of C1 plasma for children_0_3y, children_3_6y, children_6_9y in comparison to single IV administration shown as box-whisker plot, which indicates ratios of the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.
Table 1-10: Ratio of population summary statistics of Total body clearance/F of C1 plasma for children_0_3y, children_3_6y, children_6_9y in comparison to single IV administration
| Population | N | 5th pctl | 25th pctl | 50th pctl | 75th pctl | 95th pctl | Mean | SD | Geo Mean | Geo SD |
|---|---|---|---|---|---|---|---|---|---|---|
| children_0_3y | 5 | 0.72 | 0.74 | 0.52 | 0.37 | 0.32 | 0.45 | 0.25 | 0.50 | 0.78 |
| children_3_6y | 5 | 1.48 | 1.22 | 0.89 | 0.57 | 0.40 | 0.69 | 0.17 | 0.81 | 0.63 |
| children_6_9y | 5 | 0.94 | 0.78 | 0.59 | 0.37 | 0.27 | 0.46 | 0.13 | 0.53 | 0.64 |
1.1.6 Vss (plasma)/F
Figure 1-301: Vss (plasma)/F of C1 plasma for single IV administration, children_0_3y, children_3_6y, children_6_9y shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.
Figure 1-302: Vss (plasma)/F of C1 plasma for single IV administration, children_0_3y, children_3_6y, children_6_9y shown as box-whisker plot, which indicates the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.
Table 1-11: Population statistics summarizing Vss (plasma)/F of C1 plasma for single IV administration, children_0_3y, children_3_6y, children_6_9y reported in [ml/kg]
| Population | N | 5th pctl | 25th pctl | 50th pctl | 75th pctl | 95th pctl | Mean | SD | Geo Mean | Geo SD |
|---|---|---|---|---|---|---|---|---|---|---|
| single IV administration | 10 | 1819.01 | 2163.69 | 2446.94 | 3208.77 | 3393.87 | 2596.60 | 628.35 | 2526.43 | 1.28 |
| children_0_3y | 5 | 1595.31 | 1681.41 | 2156.59 | 2466.16 | 2752.86 | 2140.50 | 525.87 | 2088.68 | 1.28 |
| children_3_6y | 5 | 1497.40 | 1610.20 | 2061.71 | 2069.03 | 2078.95 | 1858.31 | 295.18 | 1838.50 | 1.18 |
| children_6_9y | 5 | 1517.33 | 1529.82 | 1595.02 | 2005.10 | 2316.77 | 1807.77 | 384.74 | 1777.44 | 1.22 |
Figure 1-303: Age-dependence of Vss (plasma)/F for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-304: Age-dependence of Vss (plasma)/F for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-305: Age-dependence of Vss (plasma)/F for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-306: Age-dependence of Vss (plasma)/F for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-307: Age-dependence of Vss (plasma)/F for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-308: Age-dependence of Vss (plasma)/F for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-309: Age-dependence of Vss (plasma)/F for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-310: Age-dependence of Vss (plasma)/F for single IV administration. Profiles are plotted in a linear scale.
Figure 1-311: Age-dependence of Vss (plasma)/F for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-312: Age-dependence of Vss (plasma)/F for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-313: Age-dependence of Vss (plasma)/F for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-314: Age-dependence of Vss (plasma)/F for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-315: Age-dependence of Vss (plasma)/F for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-316: Age-dependence of Vss (plasma)/F for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-317: Height-dependence of Vss (plasma)/F for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-318: Height-dependence of Vss (plasma)/F for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-319: Height-dependence of Vss (plasma)/F for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-320: Height-dependence of Vss (plasma)/F for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-321: Height-dependence of Vss (plasma)/F for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-322: Height-dependence of Vss (plasma)/F for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-323: Height-dependence of Vss (plasma)/F for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-324: Height-dependence of Vss (plasma)/F for single IV administration. Profiles are plotted in a linear scale.
Figure 1-325: Height-dependence of Vss (plasma)/F for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-326: Height-dependence of Vss (plasma)/F for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-327: Height-dependence of Vss (plasma)/F for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-328: Height-dependence of Vss (plasma)/F for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-329: Height-dependence of Vss (plasma)/F for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-330: Height-dependence of Vss (plasma)/F for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-331: Weight-dependence of Vss (plasma)/F for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-332: Weight-dependence of Vss (plasma)/F for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-333: Weight-dependence of Vss (plasma)/F for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-334: Weight-dependence of Vss (plasma)/F for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-335: Weight-dependence of Vss (plasma)/F for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-336: Weight-dependence of Vss (plasma)/F for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-337: Weight-dependence of Vss (plasma)/F for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-338: Weight-dependence of Vss (plasma)/F for single IV administration. Profiles are plotted in a linear scale.
Figure 1-339: Weight-dependence of Vss (plasma)/F for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-340: Weight-dependence of Vss (plasma)/F for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-341: Weight-dependence of Vss (plasma)/F for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-342: Weight-dependence of Vss (plasma)/F for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-343: Weight-dependence of Vss (plasma)/F for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-344: Weight-dependence of Vss (plasma)/F for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-345: BMI-dependence of Vss (plasma)/F for children_0_3y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-346: BMI-dependence of Vss (plasma)/F for children_0_3y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-347: BMI-dependence of Vss (plasma)/F for children_3_6y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-348: BMI-dependence of Vss (plasma)/F for children_3_6y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-349: BMI-dependence of Vss (plasma)/F for children_6_9y in comparison to single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-350: BMI-dependence of Vss (plasma)/F for children_6_9y in comparison to single IV administration. Profiles are plotted in a linear scale.
Figure 1-351: BMI-dependence of Vss (plasma)/F for single IV administration. Profiles are plotted in a logarithmic scale.
Figure 1-352: BMI-dependence of Vss (plasma)/F for single IV administration. Profiles are plotted in a linear scale.
Figure 1-353: BMI-dependence of Vss (plasma)/F for children_0_3y. Profiles are plotted in a logarithmic scale.
Figure 1-354: BMI-dependence of Vss (plasma)/F for children_0_3y. Profiles are plotted in a linear scale.
Figure 1-355: BMI-dependence of Vss (plasma)/F for children_3_6y. Profiles are plotted in a logarithmic scale.
Figure 1-356: BMI-dependence of Vss (plasma)/F for children_3_6y. Profiles are plotted in a linear scale.
Figure 1-357: BMI-dependence of Vss (plasma)/F for children_6_9y. Profiles are plotted in a logarithmic scale.
Figure 1-358: BMI-dependence of Vss (plasma)/F for children_6_9y. Profiles are plotted in a linear scale.
Figure 1-359: Ratio of population summary statistics of Vss (plasma)/F of C1 plasma for children_0_3y, children_3_6y, children_6_9y in comparison to single IV administration shown as box-whisker plot, which indicates ratios of the 5th, 25th, 50th, 75th, 95th percentiles in logarithmic scale.
Figure 1-360: Ratio of population summary statistics of Vss (plasma)/F of C1 plasma for children_0_3y, children_3_6y, children_6_9y in comparison to single IV administration shown as box-whisker plot, which indicates ratios of the 5th, 25th, 50th, 75th, 95th percentiles in linear scale.
Table 1-12: Ratio of population summary statistics of Vss (plasma)/F of C1 plasma for children_0_3y, children_3_6y, children_6_9y in comparison to single IV administration
| Population | N | 5th pctl | 25th pctl | 50th pctl | 75th pctl | 95th pctl | Mean | SD | Geo Mean | Geo SD |
|---|---|---|---|---|---|---|---|---|---|---|
| children_0_3y | 5 | 0.88 | 0.78 | 0.88 | 0.77 | 0.81 | 0.82 | 0.84 | 0.83 | 1.00 |
| children_3_6y | 5 | 0.82 | 0.74 | 0.84 | 0.64 | 0.61 | 0.72 | 0.47 | 0.73 | 0.92 |
| children_6_9y | 5 | 0.83 | 0.71 | 0.65 | 0.62 | 0.68 | 0.70 | 0.61 | 0.70 | 0.95 |
2 Time profiles and residual plots
2.1 Time profiles and residual plots for single IV administration
Figure 2-1: Time profiles for single IV administration. Time profiles are plotted in a linear scale.
Figure 2-2: Time profiles for single IV administration. Time profiles are plotted in a logarithmic scale.
2.2 Time profiles and residual plots for children_0_3y
Figure 2-3: Time profiles for children_0_3y. Time profiles are plotted in a linear scale.
Figure 2-4: Time profiles for children_0_3y. Time profiles are plotted in a logarithmic scale.
