Report NO12

Table of Contents

• 1 PK parameters
  • 1.1 PK parameters for PO administration of 320 mg
• 2 Absorption
  • 2.1 Absorption for PO administration of 320 mg
• 3 Mass Balance
  • 3.1 Mass Balance for PO administration of 320 mg
    • 3.1.1 Mass Balance for Theophylline
• 4 Time profiles and residual plots
  • 4.1 Time profiles and residual plots for PO administration of 320 mg

1 PK parameters

1.1 PK parameters for PO administration of 320 mg

Table 1-1: PK parameters for PO administration of 320 mg

Path	Parameter	Value	Unit
Theophylline	C_max	8.68	mg/l
Theophylline	t_max	1.55	h
Theophylline	C_tEnd	3.46	mg/l
Theophylline	AUC_tEnd	151.57	mg*h/l

2 Absorption

2.1 Absorption for PO administration of 320 mg

Figure 2-1: Absorption of Theophylline

3 Mass Balance

3.1 Mass Balance for PO administration of 320 mg

3.1.1 Mass Balance for Theophylline

Figure 3-1: Amount of drug vs time within the different compartments for Theophylline

Figure 3-2: Cumulated amount of drug vs time within the different compartments for Theophylline

Figure 3-3: Amount of drug vs time within the different compartments normalized to applicated drugmass for Theophylline

Figure 3-4: Cumulated amount of drug vs time within the different compartments normalized to applicated drugmass for Theophylline

Figure 3-5: Fraction of drug within the different compartments at 26.00h for Theophylline

4 Time profiles and residual plots

4.1 Time profiles and residual plots for PO administration of 320 mg

Figure 4-1: Time profiles for PO administration of 320 mg. Data source: Boeckmann 1994. Time profiles are plotted in a linear scale.

Figure 4-2: Time profiles for PO administration of 320 mg. Data source: Boeckmann 1994. Time profiles are plotted in a logarithmic scale.

Figure 4-3: Predicted vs observed for PO administration of 320 mg. Data source: Boeckmann 1994. Predictions and observations are plotted in a linear scale.

Figure 4-4: Predicted vs observed for PO administration of 320 mg. Data source: Boeckmann 1994. Predictions and observations are plotted in a logarithmic scale.

Figure 4-5: Logarithmic residuals vs predicted values for PO administration of 320 mg. Data source: Boeckmann 1994.

Figure 4-6: Logarithmic residuals vs time values for PO administration of 320 mg. Data source: Boeckmann 1994.

Figure 4-7: Logarithmic residuals distribution (stacked) for PO administration of 320 mg. Data source: Boeckmann 1994.

Figure 4-8: Logarithmic residuals for PO administration of 320 mg as quantile-quantile plot. Data source: Boeckmann 1994.