Test-NO11.Rmd1 PK parameters
1.1 PK parameters for PO320mg
Table 1-1: PK parameters for PO320mg
| Path | Parameter | Value | Unit |
|---|---|---|---|
| Theophylline plasma concentration | C_max | 8.26 | mg/l |
| Theophylline plasma concentration | t_max | 1.35 | h |
| Theophylline plasma concentration | C_tEnd | 1.16 | mg/l |
| Theophylline plasma concentration | AUC_tEnd | 99.47 | mg*h/l |
| Theophylline plasma concentration | Half-Life | 8.16 | h |
| Theophylline plasma concentration | Total body clearance/F | 0.65 | ml/min/kg |
| Theophylline plasma concentration | Vss (plasma)/F | 490.26 | ml/kg |
| Theophylline plasma concentration | Vd (plasma)/F | 456.11 | ml/kg |
2 Time profiles and residual plots
2.1 Time profiles and residual plots for PO320mg
Figure 2-1: Time profiles for PO320mg. Data source: Boeckmann 1994. Time profiles are plotted in a linear scale.
Figure 2-2: Time profiles for PO320mg. Data source: Boeckmann 1994. Time profiles are plotted in a logarithmic scale.
Figure 2-3: Predicted vs observed for PO320mg. Data source: Boeckmann 1994. Predictions and observations are plotted in a linear scale.
Figure 2-4: Predicted vs observed for PO320mg. Data source: Boeckmann 1994. Predictions and observations are plotted in a logarithmic scale.
Figure 2-5: Logarithmic residuals vs predicted values for PO320mg. Data source: Boeckmann 1994.
Figure 2-6: Logarithmic residuals vs time values for PO320mg. Data source: Boeckmann 1994.
Figure 2-7: Logarithmic residuals distribution (stacked) for PO320mg. Data source: Boeckmann 1994.
Figure 2-8: Logarithmic residuals for PO320mg as quantile-quantile plot. Data source: Boeckmann 1994.